Safety of β2-agonists: a 50-year debate closed?
نویسندگان
چکیده
Affiliations: University Hospital, Hôpital Arnaud de Villeneuve, Dept of Respiratory Diseases, Montpellier, Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology team, Villejuif, Inserm U1046, Montpellier University 1 and 2, Montpellier, and Allergy Division, Pneumology Dept, INSERM U657, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France.
منابع مشابه
Efficacy and safety of conventional long acting β2- agonists: systematic review and meta-analysis
Background: Chronic obstructive pulmonary disease (COPD) is usually considered one of the leading causes of death worldwide, so finding proper therapeutic strategies for this disease is of high importance. In this meta-analysis, we reviewed the existing literature on the efficacy and safety of conventional long acting beta agonists (LABAs) in COPD patients. Methods: We searched MEDLINE and G...
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A novel enzyme-linked receptor assay (ELRA) based on β2-adrenergic receptor (β2-AR) has been developed for rapid and high-throughput detection of β-adrenergic agonists (β-agonists) in urine. Human embryonic kidney cells (HEK293) were introduced as the expression system to enhance the functionality of the recombinant β2-AR, and the attempt to detect β-agonists in swine urine using such approache...
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Several studies suggested an association between the regular use of β2-agonists and asthma deaths. Whether this association represents adverse effects of β-agonist use or is entirely due to disease severity is a matter of ongoing debate. Previous literature indicates that confounding by poor asthma control may explain the apparent deleterious effects of inhaled β2-agonists. Tolerance to nonbron...
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Bronchodilators are central drugs in the management of patients with chronic obstructive pulmonary disease (COPD). Indacaterol was the first agent of the novel family of very long-acting β2-agonists to be used as an inhaled bronchodilator for COPD and provides 24-hour therapeutic action, thus allowing once-daily administration. Data from clinical trials show that indacaterol has a bronchodilato...
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عنوان ژورنال:
- The European respiratory journal
دوره 43 1 شماره
صفحات -
تاریخ انتشار 2014